Reference. Cardioinformatics: the nexus of bioinformatics and precision cardiology
Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17 million deaths per year, which outpaces global cancer mortality rates. Despite these sobering statistics, most bioinformatics and computational biology research and funding to date has been concentrated predominantly on cancer research, with a relatively modest footprint in CVD. In this paper, we review the existing literary landscape and critically assess the unmet need to further develop an emerging field at the multidisciplinary interface of bioinformatics and precision cardiovascular medicine, which we refer to as ‘cardioinformatics’.
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- Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery (2019)
- Dimensionality reduction for visualizing single-cell data using UMAP (2019)
- Essential guidelines for computational method benchmarking (2019)
- HeartBioPortal: an internet-of-omics for human cardiovascular disease data (2019)
- Als Knowledge Portal (2019)
- Heartbd2k—A Community Effort to Translate Protein Data to Knowledge: An Integrated Platform (2019)
- The All of Us Research Program Investigators (2019)
- All of Us Data Browser (2019)
- Relevance of multi-omics studies in cardiovascular diseases (2019)
- An open resource of structural variation for medical and population genetics (2019)
- Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics (2019)
- One Brave Idea (2019)
- Computational models in cardiology (2019)
- How artificial intelligence could redefine clinical trials in cardiovascular medicine: lessons learned from oncology (2019)
- From genetics to smart watches: developments in precision cardiology (2019)
- Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network (2019)
- An artificial intelligence-enabled ecg algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction (2019)
- Clinical value of predicting individual treatment effects for intensive blood pressure therapy (2019)
- Clinical applications of machine learning in cardiovascular disease and its relevance to cardiac imaging (2019)
- Deep learning for cardiovascular medicine: a practical primer (2019)
- Deep-learning cardiac motion analysis for human survival prediction (2019)
- Deep learning in cardiology (2019)
- The kipoi repository accelerates community exchange and reuse of predictive models for genomics (2019)
- Global, regional, and national age–sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study (2018)
- Emerging role of precision medicine in cardiovascular disease (2018)
- Chan Zuckerberg Biohub Awards $13.7 Million to Fund New Intercampus Collaborative Research Programs to Advance Human health (2018)
- Machine learning in cardiovascular medicine: are we there yet? (2018)
- Advances in transcriptomics: investigating cardiovascular disease at unprecedented resolution (2018)
- Minimap2: pairwise alignment for nucleotide sequences (2018)
- American Heart Association precision medicine platform (2018)
- Cerebrovascular Disease Knowledge Portal: an open-access data resource to accelerate genomic discoveries in stroke (2018)
- C/VDdb: a multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD) (2018)
- Single Cell Portal (2018)
- Type 2 Diabetes Knowledge Portal (2018)
- Sleep Disorder Knowledge Portal (2018)
- Cardiovascular Disease Knowledge Portal (2018)
- Cerebrovascular Disease Knowledge Portal (2018)
- Omics, big data, and precision medicine in cardiovascular sciences (2018)
- Genome-wide association studies of coronary artery disease: recent progress and challenges ahead (2018)
- A new approach to an old problem: one brave idea (2018)
- Accurate classification of BRCA1 variants with saturation genome editing (2018)
- Database of genomic variants archive (2018)
- Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy (2018)
- Deciphering non-coding RNAs in cardiovascular health and disease (2018)
- Long noncoding RNA discovery in cardiovascular disease (2018)
- LNCipedia 5: towards a reference set of human long non-coding RNAs (2018)
- mirnas in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges (2018)
- Dynamic human environmental exposome revealed by longitudinal personal monitoring (2018)
- Personal omics for precision health (2018)
- A Persons Zip Code Is the Number 1 Factor that Predicts Coronary Heart Disease. Here’s How Technology Can Change That (2018)
- New perspectives: systems medicine in cardiovascular disease (2018)
- Big data, artificial intelligence, and cardiovascular precision medicine (2018)
- Cardiovascular metabolomics (2018)
- Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients (2018)
- Defining the human envirome (2018)
- Precision profiling of the cardiovascular post-translationally modified proteome (2018)
- Biomedical informatics on the cloud: a treasure hunt for advancing cardiovascular medicine (2018)
- Cloud computing for genomic data analysis and collaboration (2018)
- Analysis of sensitive information leakage in functional genomics signal profiles through genomic deletions (2018)
- NONCODEV5: a comprehensive annotation database for long non-coding RNAs (2018)
- Biochat: a database for natural language processing of gene expression omnibus data (2018)
- Decoding the genomics of abdominal aortic aneurysm (2018)
- A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure (2018)
- Genetics of blood lipids among 300,000 multi-ethnic participants of the million veteran program (2018)
- Taking systems medicine to heart (2018)
- Integrated omics dissection of proteome dynamics during cardiac remodeling (2018)
- Machine learning in heart failure: ready for prime time (2018)
- Artificial intelligence in cardiology (2018)
- Deep echocardiography: data-efficient supervised and semi-supervised deep learning towards automated diagnosis of cardiac disease (2018)
- Deep learning in the medical domain: predicting cardiac arrest using deep learning (2018)
- An algorithm based on deep learning for predicting in-hospital cardiac arrest (2018)
- Virtual-reality applications give science a new dimension (2018)
- Emerging applications of virtual reality in cardiovascular medicine (2018)
- Phrase mining of textual data to analyze extracellular matrix protein patterns across cardiovascular disease (2018)
- Biomedical text mining for research rigor and integrity: tasks, challenges, directions (2018)
- Visualization of biomedical data (2018)
- HiGlass: web-based visual exploration and analysis of genome interaction maps (2018)
- HiPiler: visual exploration of large genome interaction matrices with interactive small multiples (2018)
- Validation of prediction models for critical care outcomes using natural language processing of electronic health record data (2018)
- Estimates of funding for various research, condition, and disease categories (RCDC) (2018)
- OMIM—Online Mendelian Inheritance in Man (2018)
- Agora (Sage Bionetworks portal) (2018)
- dbSNP (NCBI database) (2018)
- dbVar (NCBI database) (2018)
- Reducing the global burden of cardiovascular disease, part 1: the epidemiology and risk factors (2017)
- Precision medicine needs pioneering clinical bioinformaticians (2017)
- Translational bioinformatics in the era of real-time biomedical, health care and wellness data streams (2017)
- PMLB: a large benchmark suite for machine learning evaluation and comparison (2017)
- Open Targets: a platform for therapeutic target identification and validation (2017)
- The NCI Genomic Data Commons as an engine for precision medicine (2017)
- The National Genomics Research and Healthcare Knowledgebase (2017)
- China’s 100K Wellness Pioneer Project uses UniteGen and SapientiaTM integrated platform (2017)
- 10 Years of GWAS discovery: biology, function, and translation (2017)
- Enabling precision cardiology through multiscale biology and systems medicine (2017)
- The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) (2017)
- The human phenotype ontology in (2017)
- Dilated cardiomyopathy (2017)
- Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples (2017)
- Closing the genotype–phenotype loop for precision medicine (2017)
- Cardiac aging and heart disease in humans (2017)
- An expanded view of complex traits: from polygenic to omnigenic (2017)
- A rare-variant test for high-dimensional data (2017)
- Additional candidate genes for human atherosclerotic disease identified through annotation based on chromatin organization (2017)
- Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity (2017)
- Epigenome-wide association study identifies cardiac gene patterning and a novel class of biomarkers for heart failure (2017)
- High-resolution mapping of chromatin conformation in cardiac myocytes reveals structural remodeling of the epigenome in heart failure (2017)
- Micrornas and cancer: a long story for short rnas (2017)
- micrornas as cancer therapeutics: a step closer to clinical application (2017)
- Exposome-scale investigations guided by global metabolomics, pathway analysis, and cognitive computing (2017)
- Feasibility of obtaining measures of lifestyle from a smartphone app: the MyHeart counts cardiovascular health study (2017)
- Digital health: tracking physiomes and activity using wearable biosensors reveals useful health-related information (2017)
- Neighborhoods play big role in heart health, study says (2017)
- Survival Guide to Organic Chemistry: Bridging the Gap from General Chemistry (2017)
- PRINCESS: privacy-protecting rare disease international network collaboration via encryption through software guard extensions (2017)
- DataSHIELD—new directions and dimensions (2017)
- The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition (2017)
- Discovering and linking public omics data sets using the Omics Discovery Index (2017)
- Omic and electronic health record big data analytics for precision medicine (2017)
- A wellness study of 108 individuals using personal, dense, dynamic data clouds (2017)
- Large-scale physical activity data reveal worldwide activity inequality (2017)
- Using recurrent neural network models for early detection of heart failure onset (2017)
- Artificial intelligence in precision cardiovascular medicine (2017)
- Cardiac imaging: working towards fully-automated machine analysis & interpretation (2017)
- Shinyheatmap: ultra fast low memory heatmap web interface for big data genomics (2017)
- The American Heart Association’s new institute for precision cardiovascular medicine (2016)
- Toward a shared vision for cancer genomic data (2016)
- Accelerating Medicines Partnership: Alzheimer’s Disease (AMP-AD) Knowledge Portal Aids Alzheimer’s Drug Discovery through Open Data Sharing. Expert Opinion on Therapeutic Targets (2016)
- A large dataset of protein dynamics in the mammalian heart proteome (2016)
- Million Veteran Program: a mega-biobank to study genetic influences on health and disease (2016)
- Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history (2016)
- Genomic prediction of coronary heart disease (2016)
- Genetic cardiovascular risk prediction: are we already there? (2016)
- Clinical and mechanistic insights into the genetics of cardiomyopathy (2016)
- Analysis of protein-coding genetic variation in 60,706 humans (2016)
- Clinical genomics: from pathogenicity claims to quantitative risk estimates (2016)
- Inactivating variants in ANGPTL4 and risk of coronary artery disease (2016)
- Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease (2016)
- Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases (2016)
- Centers for Common Disease Genomics (CCDG) (2016)
- The role of epigenetic modifications in cardiovascular disease: a systematic review (2016)
- Ischemic preconditioning confers epigenetic repression of Mtor and induction of autophagy through G9a-dependent H3K9 dimethylation (2016)
- Epigenome-wide association study reveals differential DNA methylation in individuals with a history of myocardial infarction (2016)
- Preclinical development of a microrna-based therapy for elderly patients with myocardial infarction (2016)
- Micrornas in cardiovascular disease (2016)
- Deregulated cardiac specific micrornas in postnatal heart growth (2016)
- Cardiac-specific mirna in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction) (2016)
- Exploiting nanotechnology for the development of microrna-based cancer therapeutics (2016)
- Genetic risk, adherence to a healthy lifestyle, and coronary disease (2016)
- Computational cardiology—a new discipline of translational research (2016)
- ViPAR: a software platform for the virtual pooling and analysis of research data (2016)
- COINSTAC: a privacy enabled model and prototype for leveraging and processing decentralized brain imaging data (2016)
- Quantification of private information leakage from phenotype-genotype data: linking attacks (2016)
- 3CDB: a manually curated database of chromosome conformation capture data (2016)
- Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study (2016)
- Integrative approaches for large-scale transcriptome-wide association studies (2016)
- Dbn-extended: a dynamic bayesian network model extended with temporal abstractions for coronary heart disease prognosis (2016)
- Big data analytics to improve cardiovascular care: promise and challenges (2016)
- Vials: visualizing alternative splicing of genes (2016)
- A genetic risk score of 45 coronary artery disease risk variants associates with increased risk of myocardial infarction in 6041 Danish individuals (2015)
- Cost-effectiveness of hypertension therapy according to 2014 guidelines (2015)
- An integrated map of structural variation in 2,504 human genomes (2015)
- A global reference for human genetic variation (2015)
- The UK10K project identifies rare variants in health and disease (2015)
- Phenomapping for novel classification of heart failure with preserved ejection fraction (2015)
- Harnessing the heart of big data (2015)
- Privacy risks from genomic data-sharing beacons (2015)
- Integrative analysis of 111 reference human epigenomes (2015)
- Human genotype–phenotype databases: aims, challenges and opportunities (2015)
- 4DGenome: a comprehensive database of chromatin interactions (2015)
- lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs (2015)
- Big biomedical data and cardiovascular disease research: opportunities and challenges (2015)
- Methods of integrating data to uncover genotype-phenotype interactions (2015)
- Long-term neural and physiological phenotyping of a single human (2015)
- Personalized nutrition by prediction of glycemic responses (2015)
- Inferring dynamic gene regulatory networks in cardiac differentiation through the integration of multi-dimensional data (2015)
- Visualizing genome and systems biology: technologies, tools, implementation techniques and trends, past, present and future (2015)
- Quantitative visualization of alternative exon expression from RNA-seq data (2015)
- Epigenetics (2nd ed.) (2015)
- Trans-Omics for Precision Medicine (TOPMed) Program (2014)
- Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example (2014)
- Loss-of-function mutations in APOC3, triglycerides, and coronary disease (2014)
- Searching for missing heritability: designing rare variant association studies (2014)
- Joint analysis of functional genomic data and genome-wide association studies of 18 human traits (2014)
- The emerging role of epigenetics in cardiovascular disease (2014)
- Epigenome-wide association study of fasting blood lipids in the genetics of lipid-lowering drugs and diet network study (2014)
- DNA methylation and body-mass index: a genome-wide analysis (2014)
- Cardiovascular risk prediction in a population with the metabolic syndrome: Framingham vs (2014)
- Framework for responsible sharing of genomic and health-related data (2014)
- DataSHIELD: taking the analysis to the data, not the data to the analysis (2014)
- NCBIs database of genotypes and phenotypes: dbGaP (2014)
- ProteomeXchange provides globally coordinated proteomics data submission and dissemination (2014)
- Risk scoring for prediction of acute cardiac complications from imbalanced clinical data (2014)
- The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data (2014)
- Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal (2013)
- The Cancer Genome Atlas pan-cancer analysis project (2013)
- Integration of cardiac proteome biology and medicine by a specialized knowledgebase (2013)
- Multilocus genetic risk scores for coronary heart disease prediction (2013)
- Cardiovascular epigenetics: from DNA methylation to microRNAs (2013)
- Histone modifications for human epigenome analysis (2013)
- NCBI GEO: archive for functional genomics data sets-update (2013)
- Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data (2013)
- Addressing the class imbalance problem in medical datasets (2013)
- The cBio Cancer Genomics Portal: an open platform for exploring multidimensional cancer genomics data (2012)
- The intersection between aging and cardiovascular disease (2012)
- “Good enough solutions” and the genetics of complex diseases (2012)
- The microcosmos of cancer (2012)
- An integrated encyclopedia of DNA elements in the human genome (2012)
- Personal omics profiling reveals dynamic molecular and medical phenotypes (2012)
- Forecasting the future of cardiovascular disease in the United States (2011)
- Distinct epigenomic features in end-stage failing human hearts (2011)
- Gene expression profiling reveals renin mrna overexpression in human hypertensive kidneys and a role for micrornas (2011)
- A comparison of non-symmetric entropy-based classification trees and support vector machine for cardiovascular risk stratification (2011)
- The cardiac atlas project–an imaging database for computational modeling and statistical atlases of the heart (2011)
- Exploring subdomain variation in biomedical language (2011)
- Missing heritability and strategies for finding the underlying causes of complex disease (2010)
- Genome-wide DNA methylation profiling (2010)
- Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study (2010)
- Particulate matter air pollution and cardiovascular disease (2010)
- Next-generation genomics: an integrative approach (2010)
- Cardiovascular networks (2010)
- Active learning applied to patient-adaptive heartbeat classification (2010)
- Finding the missing heritability of complex diseases (2009)
- The many roles of histone deacetylases in development and physiology: implications for disease and therapy (2009)
- Reciprocal regulation of microrna-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions (2009)
- Computational biology for cardiovascular biomarker discovery (2009)
- Public access to genome-wide data: five views on balancing research with privacy and protection (2009)
- A systems-based framework for understanding complex metabolic and cardiovascular disorders (2009)
- DECIPHER: database of chromosomal imbalance and phenotype in humans using ensembl resources (2009)
- GEOmetadb: powerful alternative search engine for the gene expression omnibus (2008)
- A common variant on chromosome 9p21 affects the risk of myocardial infarction (2007)
- A common allele on chromosome 9 associated with coronary heart disease (2007)
- Genomewide association analysis of coronary artery disease (2007)
- Hdac2 regulates the cardiac hypertrophic response by modulating gsk3activity (2007)
- Prediction of first coronary events with the Framingham score: a systematic review (2007)
- Sequence variations in PCSK9, low LDL, and protection against coronary heart disease (2006)
- Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems (2006)
- Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology (2005)
- Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development (2004)
- The mammalian sir2protein has a role in embryogenesis and gametogenesis (2003)
- Framingham-based tools to calculate the global risk of coronary heart disease (2003)
- Are the Framingham and PROCAM coronary heart disease risk functions applicable to different European populations? The PRIME study (2003)
- Multi-ethnic study of atherosclerosis: objectives and design (2002)
- The nature and mechanisms of human gene mutation (2001)
- Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation (2001)
- The heart of genomics (2001)
- Computational methods for the identification of differential and coordinated gene expression (1999)
- Joint British recommendations on prevention of coronary heart disease in clinical practice. British Cardiac Society, British Hyperlipidaemia Association, British Hypertension Society, endorsed by the British Diabetic Association (1998)
- Prediction of coronary heart disease mortality in Busselton, Western Australia: an evaluation of the Framingham, national health epidemiologic follow up study, and WHO ERICA risk scores (1997)
- Orphanet: An Online Database of Rare Diseases and Orphan Drugs (1997)
- Women’s Health Initiative (1991)