Orthogonality is a notion based on the duality between programs and their environments used to determine when they can be safely combined. For instance, it is a powerful tool to establish termination properties in classical formal systems. It was given a general treatment with the concept of orthogonality category, of which numerous models of linear logic are instances, by Hyland and Schalk. This paper considers the subclass of focused orthogonalities. We develop a theory of fixpoint constructions in focused orthogonality categories. Central results are lifting theorems for initial algebras and final coalgebras. These crucially hinge on the insight that focused orthogonality categories are relational fibrations. The theory provides an axiomatic categorical framework for models of linear logic with least and greatest fixpoints of types. We further investigate domain-theoretic settings, showing how to lift bifree algebras, used to solve mixed-variance recursive type equations, to focused orthogonality categories.

We give an adequate denotational semantics for languages with recursive higher-order types, continuous probability distributions, and soft constraints. These are expressive languages for building Bayesian models of the kinds used in computational statistics and machine learning. Among them are untyped languages, similar to Church and WebPPL, because our semantics allows recursive mixed-variance datatypes. Our semantics justifies important program equivalences including commutativity. Our new semantic model is based on ‘quasi-Borel predomains’. These are a mixture of chain-complete partial orders (cpos) and quasi-Borel spaces. Quasi-Borel spaces are a recent model of probability theory that focuses on sets of admissible random elements. Probability is traditionally treated in cpo models using probabilistic powerdomains, but these are not known to be commutative on any class of cpos with higher order functions. By contrast, quasi-Borel predomains do support both a commutative probabilistic powerdomain and higher-order functions. As we show, quasi-Borel predomains form both a model of Fiore’s axiomatic domain theory and a model of Kock’s synthetic measure theory.

We develop a theory of abstract syntax with variable binding. To every binding signature we associate a category of models consisting of variable sets endowed with compatible algebra and substitution structures. The syntax generated by the signature is the initial model. This gives a notion of initial algebra semantics encompassing the traditional one; besides compositionality, it automatically verifies the semantic substitution lemma.